Opioid Agonist
Where is Tapentadol made?
7 companies sell it under their own name and 3 repackagers rebottle it. Their labels name 7 factories in the United States.
United States 7
Companies and their factories
| Company on the label | Factory | Where | Last FDA inspection |
|---|---|---|---|
| Collegium Pharmaceutical, Inc. Nucynta, NucyntaER50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 250 mg · NDC 24510-100, 24510-116, 24510-174 +5 | Halo Pharmaceutical IncMakes it and tests it | Whippany, NJ, United States | No problems foundDec 2025 |
| Janssen Ortho LLCMakes it and tests it | Gurabo, PR, United States | Problems found, fixed voluntarilyMar 2023 | |
| Janssen Pharmaceuticals, Inc.Makes the active ingredient | Athens, GA, United States | Problems found, fixed voluntarilyJan 2025 | |
| Patheon Pharmaceuticals Inc.Makes it | Cincinnati, OH, United States | Problems found, fixed voluntarilySep 2025 | |
| Depo NF Sub, LLC NucyntaER, Nucynta50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 250 mg · NDC 69865-245, 69865-230, 69865-250 +5 | Janssen Ortho LLCMakes it and tests it | Gurabo, PR, United States | Problems found, fixed voluntarilyMar 2023 |
| Janssen Pharmaceuticals, Inc.Makes the active ingredient | Athens, GA, United States | Problems found, fixed voluntarilyJan 2025 | |
| ANI Pharmaceuticals, Inc.20 mg per 1 mL · NDC 70954-801 | Novitium Pharma LLCMakes it, tests it, packages it and labels it | East Windsor, NJ, United States | No problems foundFeb 2024 |
| Epic Pharma, LLC50 mg, 75 mg, 100 mg · NDC 42806-628, 42806-626, 42806-627 | Epic Pharma, LLCMakes it | Laurelton, NY, United States | Problems found, fixed voluntarilyJun 2026 |
| Novadoz Pharmaceuticals LLC50 mg, 75 mg, 100 mg · NDC 72205-371, 72205-369, 72205-370 | MSN Pharmaceuticals IncMakes it and tests it | Piscataway, NJ, United States | No problems foundMar 2026 |
| AvKARE, Inc.50 mg, 75 mg, 100 mg · NDC 73190-083, 73190-081, 73190-082 | The label doesn't name the factory. Plants this company names for other drugs | ||
| Hikma Pharmaceuticals USA Inc.50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 250 mg · NDC 0054-0937, 0054-0945, 0054-0938 +5 | The label doesn't name the factory. Plants this company names for other drugs | ||
Repackaged by
These companies buy Tapentadol in bulk and rebottle it, often for mail-order, clinic or hospital pharmacies. If your bottle shows one of these names, open its NDC to see who made the pills inside.
- Physicians Total Care, Inc.:
54868-6039,54868-5979,54868-6002 - Rebel Distributors Corp..:
21695-069 - Stat Rx USA:
16590-289,16590-863,16590-889