Vascular Endothelial Growth Factor Inhibitor
Where is Aflibercept made?
6 companies sell it under their own name. Their labels name 11 factories in the United States, Italy, Germany, the United Kingdom, South Korea and Ireland.
United States 4Italy 2Germany 2United Kingdom 1South Korea 1Ireland 1
Companies and their factories
| Company on the label | Factory | Where | Last FDA inspection |
|---|---|---|---|
| Regeneron Pharmaceuticals, Inc. Eylea, Eylea Hd8 mg per 0.07 mL, 40 mg per 1 mL · NDC 61755-005, 61755-050, 61755-051 | Catalent Indiana, LLCMakes it | Bloomington, IN, United States | Serious problems, FDA actionApr 2026 |
| Regeneron Ireland Designated Activity CompanyMakes it, makes the active ingredient and tests it | Limerick, Ireland | Problems found, fixed voluntarilyJun 2025 | |
| Regeneron Pharmaceuticals, Inc.Makes it, makes the active ingredient and tests it | Rensselaer, NY, United States | Problems found, fixed voluntarilyMar 2024 | |
| Sharp Packaging Services, LLCMakes it, packages it and labels it | Allentown, PA, United States | No problems foundNov 2025 | |
| Simtra US LLCMakes it, tests it, packages it and labels it | Bloomington, IN, United States | Problems found, fixed voluntarilySep 2024 | |
| Vetter Pharma Fertigung GmbH & Co. KG (Langenargen Eisenbahnstrasse)Makes it and tests it | Langenargen, Germany | Problems found, fixed voluntarilyMar 2024 | |
| CELLTRION USA, Inc. EYDENZELTboav2 mg per 0.05 mL · NDC 72606-026 | Bioreliance Ltd.Makes it and tests it | Glasgow Lanarkshire, United Kingdom | Problems found, fixed voluntarilyMay 2026 |
| CELLTRION IncMakes the active ingredient and tests it | Incheon, South Korea | Problems found, fixed voluntarilyMay 2024 | |
| Patheon Italia S.p.AMakes it and tests it | Ferentino, Italy | Problems found, fixed voluntarilyFeb 2022 | |
| Patheon Italia S.p.A.Makes it and tests it | Monza, Italy | Problems found, fixed voluntarilyMay 2023 | |
| Sanofi-Aventis U.S. LLC Zaltrap100 mg per 4 mL, 200 mg per 8 mL · NDC 0024-5840, 0024-5841 | Regeneron Pharmaceuticals, Inc.Makes the active ingredient and tests it | Rensselaer, NY, United States | Problems found, fixed voluntarilyMar 2024 |
| Sanofi-Aventis Deutschland GmbHMakes it, tests it, packages it and labels it | Frankfurt am Main, Germany | Problems found, fixed voluntarilyMar 2022 | |
| Amgen Inc Pavblu2 mg per 0.05 mL · NDC 55513-056, 55513-065 | The label doesn't name the factory. Plants this company names for other drugs | ||
| Biocon Biologics Inc. Yesafili2 mg per 0.05 mL · NDC 83257-035, 83257-013 | The label doesn't name the factory. Plants this company names for other drugs | ||
| Sandoz Inc. Enzeevu2 mg per 0.05 mL · NDC 61314-504 | The label doesn't name the factory. Plants this company names for other drugs | ||
Recalls
- May 15, 2024 · Class II · Regeneron Pharmaceuticals Inc
Lack of Assurance of Sterility: Complaints of syringe breakage - Apr 23, 2024 · Class II · Regeneron Pharmaceuticals Inc
Lack of Assurance of Sterility: Complaints of syringe breakage
Class I recalls are the most serious; Class III the least. A recall covers specific lots, listed on each recall.