Biguanide, Peroxisome Proliferator Receptor alpha Agonist

Where is Metformin and Pioglitazone made?

5 companies sell it under their own name and 3 repackagers rebottle it. Their labels name 8 factories in India, Japan, Spain, Ireland and France.

India 3Japan 2Spain 1Ireland 1France 1
India: 3Japan: 2Spain: 1Ireland: 1France: 1

Companies and their factories

Company on the labelFactoryWhereLast FDA inspection
Takeda Pharmaceuticals America, Inc. Actoplus Met15 mg / 850 mg · NDC 64764-158 Daito Pharmaceutical Co., LtdMakes it and tests it Toyama-City, JapanProblems found, fixed voluntarilyDec 2023
Farmhispania S.A.Makes the active ingredient Montmelo, SpainProblems found, fixed voluntarilyMay 2023
Juzen Chemical CorporationMakes the active ingredient Toyama-city, JapanProblems found, fixed voluntarilyAug 2025
Takeda Ireland LimitedMakes it Dublin, IrelandProblems found, fixed voluntarilyJul 2023
Zach System S.a.Makes the active ingredient Avrille, FranceProblems found, fixed voluntarilyFeb 2021
Aurobindo Pharma Limited15 mg / 500 mg, 15 mg / 850 mg · NDC 65862-525, 65862-526 Aurobindo Pharma LimitedMakes it and tests it Mahabubnagar, IndiaProblems found, fixed voluntarilyMay 2022
Macleods Pharmaceuticals Limited15 mg / 500 mg, 15 mg / 850 mg · NDC 33342-176, 33342-177 Macleods Pharmaceuticals LimitedMakes it, tests it, packages it and labels it District Solan, IndiaProblems found, fixed voluntarilyOct 2023
Rising Pharma Holdings, Inc.15 mg / 500 mg, 15 mg / 850 mg · NDC 57237-217, 57237-218 Aurobindo Pharma LimitedMakes it and tests it Mahabubnagar, IndiaProblems found, fixed voluntarilyMay 2022
Torrent Pharma, Inc.15 mg / 500 mg, 15 mg / 850 mg · NDC 13668-280, 13668-281 Torrent Pharmaceuticals LimitedMakes it Indrad, IndiaProblems found, fixed voluntarilyJun 2024

Repackaged by

These companies buy Metformin and Pioglitazone in bulk and rebottle it, often for mail-order, clinic or hospital pharmacies. If your bottle shows one of these names, open its NDC to see who made the pills inside.