Angiotensin Converting Enzyme Inhibitor, Thiazide Diuretic
Where is Hydrochlorothiazide and Lisinopril made?
10 companies sell it under their own name and 28 repackagers rebottle it. Their labels name 10 factories in India, the United States and Italy.
India 6United States 3Italy 1
Companies and their factories
| Company on the label | Factory | Where | Last FDA inspection |
|---|---|---|---|
| Ranbaxy Laboratories Inc.10 mg / 12.5 mg, 20 mg / 12.5 mg, 20 mg / 25 mg · NDC 63304-536, 63304-537, 63304-538 | Cambrex Profarmaco Milano SRLMakes the active ingredient | Paullo, Italy | No problems foundNov 2022 |
| Matrix Pharmacorp Private LimitedMakes the active ingredient | Hyderabad, India | Problems found, fixed voluntarilyNov 2025 | |
| Ohm Laboratories Inc.Makes it and packages it | North Brunswick, NJ, United States | No problems foundOct 2024 | |
| Ranbaxy laboratories Limited ToansaMakes the active ingredient | Location not on file | Not inspected on record | |
| Lupin Pharmaceuticals, Inc.10 mg / 12.5 mg, 20 mg / 12.5 mg, 20 mg / 25 mg · NDC 68180-518, 68180-519, 68180-520 | Lupin LimitedMakes it and packages it | Salcette, India | Problems found, fixed voluntarilyNov 2025 |
| Lupin LimitedMakes it and packages it | Pithampur, India | Serious problems, FDA actionJul 2025 | |
| Lupin LimitedMakes it and packages it | Nagpur, India | Problems found, fixed voluntarilyJul 2023 | |
| Aurobindo Pharma Limited10 mg / 12.5 mg, 20 mg / 12.5 mg, 20 mg / 25 mg · NDC 65862-043, 65862-044, 65862-045 | Apl Healthcare LimitedMakes it and tests it | Tirupati, India | Problems found, fixed voluntarilyDec 2025 |
| Aurobindo Pharma LimitedMakes it and tests it | Medchal, India | Problems found, fixed voluntarilyJul 2023 | |
| Cipla USA., Inc.10 mg / 12.5 mg, 20 mg / 12.5 mg, 20 mg / 25 mg · NDC 69097-968, 69097-969, 69097-971 | InvaGen Pharmaceuticals, IncMakes it and tests it | Hauppauge, NY, United States | No problems foundOct 2023 |
| Exelan Pharmaceuticals, Inc.10 mg / 12.5 mg, 20 mg / 12.5 mg, 20 mg / 25 mg · NDC 76282-446, 76282-447, 76282-448 | InvaGen Pharmaceuticals, IncMakes it and tests it | Hauppauge, NY, United States | No problems foundOct 2023 |
| Golden State Medical Supply, Inc.10 mg / 12.5 mg, 20 mg / 12.5 mg, 20 mg / 25 mg · NDC 51407-564, 51407-565, 51407-566 | CorePharma, LLCMakes it and packages it | Middlesex, NJ, United States | No problems foundAug 2025 |
| Actavis Pharma, Inc.10 mg / 12.5 mg, 20 mg / 12.5 mg, 20 mg / 25 mg · NDC 0591-0860, 0591-0861, 0591-0862 | The label doesn't name the factory. Plants this company names for other drugs | ||
| Almatica Pharma Inc. Zestoretic10 mg / 12.5 mg, 20 mg / 12.5 mg, 20 mg / 25 mg · NDC 52427-435, 52427-436, 52427-437 | The label doesn't name the factory. Plants this company names for other drugs | ||
| International Laboratories, LLC10 mg / 12.5 mg, 20 mg / 12.5 mg, 20 mg / 25 mg · NDC 54458-886, 54458-993, 54458-992 +1 | The label doesn't name the factory. Plants this company names for other drugs | ||
| Solco Healthcare U.S., LLC10 mg / 12.5 mg, 20 mg / 12.5 mg, 20 mg / 25 mg · NDC 43547-420, 43547-421, 43547-422 | The label doesn't name the factory. Plants this company names for other drugs | ||
Repackaged by
These companies buy Hydrochlorothiazide and Lisinopril in bulk and rebottle it, often for mail-order, clinic or hospital pharmacies. If your bottle shows one of these names, open its NDC to see who made the pills inside.
- A-S Medication Solutions:
50090-6094,50090-6062,50090-6838,50090-2565+8 - Advanced Rx Pharmacy of Tennessee, LLC:
80425-0207 - Aidarex Pharmaceuticals LLC:
33261-828,33261-416,33261-728 - Aphena Pharma Solutions - Tennessee, Inc.:
43353-866,71610-382,43353-865,71610-274+8 - Blenheim Pharmacal, Inc.:
10544-236,10544-564,10544-237 - Bryant Ranch Prepack:
71335-0060,71335-1992,71335-2102,71335-0479+9 - Coupler Enterprises Inc.:
67046-433 - Coupler LLC:
67046-0686,67046-0433 - Denton Pharma, Inc. DBA Northwind Pharmaceuticals.:
70934-128,70934-718 - Direct Rx:
61919-970,61919-308,61919-523,72189-651+1 - Dispensing Solutions Inc.:
66336-572 - H.J. Harkins Co., Inc.:
52959-997 - Legacy Pharmaceutical Packaging:
68645-556,68645-557,68645-558 - MedVantx, Inc.:
66116-300 - Northwind Pharmaceuticals:
51655-412,51655-414,51655-311,51655-413 - NuCare Pharmaceuticals.Inc.:
68071-2691,68071-3008,68071-2183,68071-2291+7 - PD-Rx Pharmaceuticals, Inc.:
43063-482,43063-458,43063-468 - Physicians Total Care, Inc.:
54868-4977,54868-4637,54868-4785 - Preferred Pharmaceuticals, Inc..:
68788-9807,68788-8224,68788-9809,68788-8253+2 - Proficient Rx LP:
63187-319,82804-307,71205-022,63187-050+3 - QPharma, Inc.:
42708-034,42708-150 - RPK Pharmaceuticals, Inc.:
53002-2308,53002-1308,53002-1674 - Rebel Distributors Corp..:
21695-733,21695-734,21695-735 - RedPharm Drug. Inc.:
67296-1691,67296-0920,67296-0921 - Remedyrepack Inc.:
70518-0196,70518-4516,70518-0382,70518-3505+1 - St. Mary's Medical Park Pharmacy:
60760-063,60760-586,60760-519 - Stat Rx USA:
16590-308,16590-309 - State of Florida DOH Central Pharmacy:
53808-0453,53808-0452,53808-0451
Recalls
- Jun 20, 2025 · Class II · Lupin Pharmaceuticals Inc.
Product Mix Up: This product is being recalled because of a complaint received that a sealed bottle of lisinopril and hydrochlorothiazide tablets 20mg/12.5 mg had a foreign tablet identified as atazanavir and ritonavir tablet 300mg/100mg. - Jan 26, 2022 · Class II · Cardinal Healthcare
CGMP Deviations: Products were exposed to temperatures outside of the products labeled storage conditions. - Jul 19, 2019 · Class II · Lupin Pharmaceuticals Inc.
Presence of Foreign Tablets/Capsules: Product complaint received of one Fenofibrate tablet 145mg observed in 500 s count product bottle. - Jul 17, 2019 · Class II · Lupin Pharmaceuticals Inc.
Presence of Foreign Substance; Product complaints received related to brownish/blackish stains on the tablets and brownish/blackish powder observed inside the bottles. - Apr 4, 2016 · Class III · Lupin Pharmaceuticals Inc.
CGMP Deviations: finished products manufactured using active pharmaceutical ingredients whose intermediates failed specifications.
Class I recalls are the most serious; Class III the least. A recall covers specific lots, listed on each recall.